The Inverse Relationship between Acute Myocardial Infarction and Dissolved Oxygen Levels in Water
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Abstract
Stroke and acute myocardial infarction are primary global causes of mortality. Statistical studies have shown that acute myocardial infarction is responsible for around 9 million deaths each year. Ischemic stroke and myocardial infarction have a significant role in global adult physical disabilities. While reperfusion is vital for tissue recovery, it may paradoxically, inadvertently increase damage through oxidative stress, inflammation, and cell death. Early reperfusion procedures are currently the sole therapy to reduce infarct size.
There are many mysteries about heart biology. It is not known the source of energy for myocardial tissues. The heart-beating force (120 mm Hg) cannot explain how erythrocytes are impelled through almost 95,000 km of capillaries in less than 5 minutes. A better knowledge of how the heart is oxygenated should allow the development of new therapies.
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Ojha N, Dhamoon AS. Myocardial Infarction. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2025. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537076/
Chang J, Deng Q, Hu P, Guo M, Lu F, Su Y, et al. Geographic Variation in Mortality of Acute Myocardial Infarction and Association With Health Care Accessibility in Beijing, 2007 to 2018. J Am Heart Assoc. 2023 Jun 20;12(12):e029769. Available from: https://doi.org/10.1161/jaha.123.029769
Piccard M, Roussot A, Cottenet J, Cottin Y, Zeller M, Quantin C. Spatial distribution of in- and out-of-hospital mortality one year after acute myocardial infarction in France. Am J Prev Cardiol. 2020;2:100037. Available from: https://doi.org/10.1016/j.ajpc.2020.100037
Ministry of Health. Drinking Water in France 2005–2006. 2008;63. [cited 20 Nov 2017]. Available from: http://solidarites-sante.gouv.fr/IMG/pdf/bilanqualite_05_06.pdf
EFSA. 2020. [retrieved: January 27, 2025]. Available from: https://www.efsa.europa.eu/en/news/pfas-food-efsa-assesses-risks-and-sets-tolerable-intake
Lacalamita D, Mongiovi C, Frini G. Front. Environ. Sci., 07 Apr 2024, Sec. Water and Wastewater Management. 2024;12. Available from: https://doi.org/10.3389/fenvs.2024.1387041
Sibil R, Berkun M, Bekiroglu S. The comparison of different mathematical methods to determine the BOD parameters, a new developed method and impacts of these parameters variations on the design of WWTPs. Appl Math Model. 2014;38:641-658. Available from: https://doi.org/10.1016/j.apm.2013.07.013
Yu B, Akushevich I, Yashkin AP, Yashin AI, Lyerly HK, Kravchenko J. Epidemiology of geographic disparities in heart failure among US older adults: a Medicare-based analysis. BMC Public Health. 2022;22(1):1280. Available from: https://doi.org/10.1186/s12889-022-13639-2
World Population Review. Life expectancy by state 2020. 2020. [cited 6 Aug 2020]. Available from: https://worldpopulationreview.com/state-rankings/life-expectancy-by-state
Yu B, Akushevich I, Yashkin A, Yashin A, Lyerly H, Kravchenko J. Heart failure mortality, incidence, prevalence, and survival in the United States: analysis of geographic disparities among older adults using Medicare data. In: Population Association of America Annual Meeting 2021. 2020. Available from: https://doi.org/10.1186/s12889-022-13639-2
Centers for Disease Control and Prevention. Heart Failure. 2019. [cited 20 May 2020].
University of Wisconsin, Population Health Institute. Louisiana, 2022, State Report. 2022 County Health Rankings for the 64 Ranked Parishes in Louisiana. Retrieved Jan 17, 2025. Available from: https://www.countyhealthrankings.org/sites/default/files/media/document/CHR2022_LA_0.pdf
EPA. EPA Comptox Dashboard. [accessed Jan 23, 2025]. Available from: https://comptox.epa.gov/dashboard/chemical-lists/pfasmaster
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Division on Earth and Life Studies; Board on Population Health and Public Health Practice; Board on Environmental Studies and Toxicology; Committee on the Guidance on PFAS Testing and Health Outcomes. Guidance on PFAS Exposure, Testing, and Clinical Follow-Up. Washington (DC): National Academies Press (US); 2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK584702/
Silver M, Phelps W, Masarik K, Burke K, Zhang C, Schwartz A, et al. Prevalence and Source Tracing of PFAS in Shallow Groundwater Used for Drinking Water in Wisconsin, USA. Environ Sci Technol. 2023;57(45):17415-17426. Available from: https://pubs.acs.org/doi/10.1021/acs.est.3c02826
Mueller R, Salvatore D, Brown P, Cordner A. Quantifying Disparities in Per- and Polyfluoroalkyl Substances (PFAS) Levels in Drinking Water from Overburdened Communities in New Jersey, 2019-2021. Environ Health Perspect. 2024;132(4):47011. Available from: https://doi.org/10.1289/ehp12787
Agyeman J, Schlosberg D, Craven L, Matthews C. Trends and directions in environmental justice: from inequity to everyday life, community, and just sustainabilities. Annu Rev Environ Resour. 2016;41(1):321–340. Available from: https://doi.org/10.1146/annurev-environ-110615-090052
Solís Herrera A, Arias Esparza MdC. Oxygen from the Atmosphere Cannot Pass Through the Lung Tissues and Reach the Bloodstream. The Unexpected Capacity of Human Body to Dissociate the Water Molecule. J Pulmonol Res Rep. 2022;SRC/JPRR-133. Available from: https://www.onlinescientificresearch.com/abstract/oxygen-from-the-atmosphere-cannot-pass-through-the-lung-tissues-and-reach-the-bloodstream-the-unexpected-capacity-of-human-body-to-1804.html
Karnkowska A, Vacek V, Zubáčová Z, Treitli SC, Petrželková R, Eme L, et al. A Eukaryote without a Mitochondrial Organelle. Curr Biol. 2016;26(10):1274–1284. Available from: https://doi.org/10.1016/j.cub.2016.03.053
Solís Herrera A. The Biological Pigments in Plants Physiology. Agric Sci. 2015;6(6):1262–1271. Available from: https://www.scirp.org/journal/paperinformation?paperid=60724
West JB. Three classical papers in respiratory physiology by Christian Bohr (1855-1911) whose work is frequently cited but seldom read. Am J Physiol Lung Cell Mol Physiol. 2019;316(4):L585-L588. Available from: https://doi.org/10.1152/ajplung.00527.2018
Ingwall JS. ATP and the Heart. Norwell, Massachusetts: Kluwer Academic Publishers. 2002. Available from: https://link.springer.com/book/10.1007/978-1-4615-1093-2
Suga H. Ventricular energetics. Physiol Rev. 1990;70:247–277. Available from: https://doi.org/10.1152/physrev.1990.70.2.247
Beer M, Seyfarth T, Sandstede J, Landschütz W, Lipke C, Köstler H, et al. Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol. 2002;40:1267–1274. Available from: https://doi.org/10.1016/S0735-1097(02)02160-5
Wisneski JA, Gertz EW, Neese RA, Gruenke LD, Craig JC. Dual carbon-labeled isotope experiments using D-[6-14C] glucose and L-[1,2,3-13C3] lactate: a new approach for investigating human myocardial metabolism during ischemia. J Am Coll Cardiol. 1985;5:1138–1146. Available from: https://doi.org/10.1016/s0735-1097(85)80016-4
Ward PS, Thompson CB. Signaling in control of cell growth and metabolism. Cold Spring Harb Perspect Biol. 2012;4:a006783. Available from: https://doi.org/10.1101/cshperspect.a006783
Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall SE, et al. Impaired Myocardial Energetics Causes Mechanical Dysfunction in Decompensated Failing Hearts. Function. 2020. Available from: https://doi.org/10.1093/function/zqaa018
Wu F, Zhang EY, Zhang J, Bache RJ, Beard DA. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts. J Physiol. 2008;586(17):4193–4208. Available from: https://doi.org/10.1113/jphysiol.2008.154732
Holzem KM, Vinnakota KC, Ravikumar VK, Madden EJ, Ewald GA, Dikranian K, et al. Mitochondrial structure and function are not different between nonfailing donor and end-stage failing human hearts. FASEB J. 2016;30(8):2698–2707. Available from: https://doi.org/10.1096/fj.201500118r
Cordero-Reyes AM, Gupte AA, Youker KA, Loebe M, Hsueh WA, Torre-Amione G, et al. Freshly isolated mitochondria from failing human hearts exhibit preserved respiratory function. J Mol Cell Cardiol. 2014;68:98–105. Available from: https://doi.org/10.1016/j.yjmcc.2013.12.029
Stride N, Larsen S, Hey-Mogensen M, Sander K, Lund JT, Gustafsson F, et al. Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. Eur J Heart Fail. 2013;15(2):150–157. Available from: https://doi.org/10.1093/eurjhf/hfs172
Hirsch GA, Bottomley PA, Gerstenblith G, Weiss RG. Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol. 2012;59:802–808. Available from: https://doi.org/10.1016/j.jacc.2011.10.895
Struthers AD, Donnan PT, Lindsay P, McNaughton D, Broomhall J, MacDonald TM. Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study. Heart. 2002;87:229–234. Available from: https://doi.org/10.1136/heart.87.3.229
Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients: the Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:154–160. Available from: https://doi.org/10.1056/nejm200001203420302
Doenst T, Nguyen TD, Abel ED. Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res. 2013;113(6):709–724. Available from: https://doi.org/10.1161/circresaha.113.300376
Herrera AS, del Carmen Arias Esparza M, Solís Arias PE, Ávila-Rodriguez M, Barreto GE, Li Y, Bachurin SO, et al. Unsuspected Intrinsic Property of Melanin to Dissociate Water Can Be Used for the Treatment of CNS Diseases. CNS Neurol Disord Drug Targets. 2016;15(2):135-140. Available from: https://doi.org/10.2174/1871527315666160202122943
Warren-Vega WM, Campos-Rodríguez A, Zárate-Guzmán AI, Romero-Cano LA. A current review of water pollutants in the American continent: trends and perspectives in detection, health risks, and treatment technologies. Int J Environ Res Public Health. 2023;20(5):4499. Available from: https://doi.org/10.3390/ijerpH20054499
Abily M, Acuña V, Corominas L, Rodríguez-Roda I, Gernjak W. Strategic routes for wastewater treatment plant upgrades to reduce micropollutants in European surface water bodies. J Clean Prod. 2023;415:137867. Available from: https://doi.org/10.1016/j.jclepro.2023.137867
Rizzo L, Malato S, Antakyali D, Beretsou VG, Đolić MB, Gernjak W, et al. Consolidated vs new advanced treatment methods for the removal of contaminants of emerging concern from urban wastewater. Sci Total Environ. 2019;655:986–1008. Available from: https://doi.org/10.1016/j.scitotenv.2018.11.265
Kanazawa S. Temperature and evolutionary novelty as forces behind the evolution of general intelligence. Intelligence. 2008;36(2):99–108. Available from: https://www.sciencedirect.com/science/article/pii/S0160289607000669